Zhongke Runxin (Suzhou) Biotechnology Co., Ltd
Zhongke Runxin (Suzhou) Biotechnology Co., Ltd
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Anti-Osteoporotic Ginsenoside Rg3 For Functional Food Ingredients
【Product Introductions】
♦ Extremely rare tetracyclic triterpenoid saponins
♦ Two isomers: 20 (S) - Rg3 and 20 (R) - Rg3
♦ The content of Rg3 in natural ginseng is extremely low, about 0.3 parts per 100000
♦ CASOLIG RG3 has an Rg3 content of ≥ 50% and a total rare saponin content of ≥ 75%
【CASOLIG RG3 component information】
| No | Batch | Total saponins | Rare saponins | Rg3 | Rg3(S) | Rg3(R) | Rk1 | Rg5 | Rh2 | Rb1 | Rc | Rd |
| 1 | RX20250404 | 87.78% | 74.72% | 52.69% | 23.69% | 29.00% | 4.77% | 14.85% | 2.41% | 3.68% | 6.31% | 3.07% |
| 2 | RX20250408 | 90.21% | 78.28% | 55.78% | 22.46% | 33.32% | 4.81% | 15.23% | 2.46% | 2.07% | 6.94% | 2.92% |
| 3 | RX20250415 | 88.12% | 77.45% | 53.49% | 22.17% | 31.32% | 5.06% | 16.36% | 2.55% | 1.70% | 5.87% | 3.11% |
| 4 | RX20250421 | 87.25% | 76.12% | 51.52% | 17.96% | 33.56% | 4.53% | 16.87% | 3.21% | 0.99% | 7.30% | 2.84% |
| 5 | RX20250423 | 89.86% | 79.02% | 54.04% | 21.76% | 32.29% | 5.27% | 17.20% | 2.50% | 1.61% | 6.47% | 2.76% |
| - | Average Value | 88.65% | 77.12% | 53.50% | 21.61% | 31.90% | 4.89% | 16.1% | 2.63% | 2.01% | 6.58% | 2.94% |
【CASOLIG RG3 Chromatogram】
【CASOLIG RG3 Principle of Anti Osteoporosis】
Ginsenoside Rg3 reduces the expression of KPNA2, decreases the activity of nuclear transport proteins, inhibits nuclear transport of pro-inflammatory and osteoclastogenetic related genes, thereby reducing osteoclast formation and activity. Reduce osteoclastogenesis by inhibiting the activation of NF - κ B.
【CASOLIG RG3 Anti osteoporosis test data】
♦ Compared with the model group, 10 μ M/L Rg3 reduced KNPA2 expression by 54%, showing the best effect
♦ The expression level of 10 μ M/L Rg3 KPNA2 protein had the lightest color, and the expression level of the internal reference protein β - actin remained unchanged, verifying the accuracy of the experimental protein expression level
【CASOLIG RG3 Conclusion】
Ginsenoside Rg3 alleviates osteoporosis symptoms by regulating the KPNA2 and NF - κ B signaling pathways, inhibiting pro-inflammatory and osteoclastogenesis